Dr. Siddharth Sharma
Associate Professor

Designation:

Associate Professor

Specialization:

Cancer Biology

Email:

siddharthsharma.phd@thapar.edu

ACADEMIC PREPARATION

  1. 2007-2009, Post-Doctoral Fellow, Department of Pathology, Miller School of Medicine, University of Miami Florida, USA
  2. 2005-2006, Post-Doctoral Fellow, Department of Molecular and cellular biology University of Cape Town
  3. 2004, Ph.D; Department of Biotechnology, Panjab University, Chandigarh Biotechnology (Cancer genetics)
  4. 1998, M.Sc; Life Sciences School of life sciences Pondicherry Central University Pondicherry                         
  5. 1996, BSc; Botany; University of Madras, Madras

 

POSITIONS HELD

1. Thapar Institute of Engineering & Technology, Patiala (7 years)

  • Associate Professor, (July-2017-current) Department of Biotechnology,
  • Assistant Professor (July 2011-2017) Department of Biotechnology

2. Application-Scientist (August 2009-June 2011) in Flow Cytometry, Beckman Coulter Pvt. Ltd

3. Post-Doctoral Fellow (2007-2009), Department of Pathology, Miller School of Medicine, University of Miami Florida, USA

4. Post-Doctoral Fellow (2005-2006), Department of Molecular and cellular biology University of Cape Town        

5. Research Associate (Scientist Grade II) (2002-2004) Department of Biotechnology, National Institute of Pharmaceutical education and Research (NIPER), Mohali

6. Research Scientist Ranbaxy Research Laboratory, Gurgaon

PROFESSIONAL SYNOPSIS

Over 14 years of Research experience in the area of molecular biology and cell biology. I obtained my Ph.D on a research project titled “Studies on the molecular alterations in the pathogenesis of small cell and non-small cell lung carcinomas”. This work involved detecting novel markers if any for early risk assessment and diagnosis of lung cancers. I further enhanced my research domain by working as an RA in NIPER, where I worked on the role of oxidative stress genes and risk towards oral carcinogenesis in North Indian populations. Initial work was on the caloric restriction of yeasts and its influence on aging, apart from this I also was involved in the cloning of phytase gene from AspergiI!us niger var. teigham in Pichia pstoris. After my stint in NIPER I moved to the pharma industry and joined Ranbaxy laboratories where I was involved in the cloning of ion channel genes and also Muscaranic receptor genes. Here I was involved in the cloning of cDNAs encoding for five Muscaranic subtypes (M1-M5) in different promoters in various eukaryotic vectors and its expression in different mammalian cell lines.

I then joined as a post-doctoral fellow in an industry sponsored in the Centre for Proteomics and Genomic  Research  in  the Institute  of  Infectious  Diseases  and  Molecular  Medicine, University of  Cape Town, South Africa. My collaborative project with Procognia (a London based proteomics company) was focused on cloning and expression of genes involved in drug metabolism in E.coli and Baculovirus for the creation of functional protein array.  I did my second post-doctoral research in the Department of Pathology, University of Miami Miller School of Medicine. Here I worked in the area of hematopoietic stems cells and used flow cytometry approach to simultaneously measure Electronic Cell Volume and marker expression to study stem cells in HPC-A samples for patients undergoing bone marrow transplantation.

RESEARCH DOMAINS (Medical Biotech): SNP related Risk assessment, Biomarker discovery, Polymorphism relation to cancer clinical outcomes, Molecular markers for lung cancer prognosis, Protein Microarrays.

AREA OF RESEARCH:

My lab is focused on Molecular profiling of lung cancer – a) Risk assessment (b) Biomarker expression related especially clinical outcomes.

(a)We have assessed, and published data related to the molecular epidemiology of lung cancer. Our primary area of research is related to the genetic epidemiology of lung tumors in North Indian population. Since genetic background has an important role in susceptibility to complex diseases including lung cancer, and the genetic contribution to disease phenotypes varies between populations, our work has helped us to identify key Single Nucleotide Polymorphism (SNPs) which are associated with individual susceptibility for lung carcinogenesis. Secondly, we have also identified the role of polymorphic variants of certain genes and their synergistic interaction with environmental stimuli. Thus, we are better able to understand the mechanisms through which environmental exposure interacts with cancer susceptibility genes which might open up new avenues for disease prevention. Genomic approaches have yielded important insight into genetic mechanisms of susceptibility to many complex traits and diseases. Furthermore, these approaches have the potential to identify disease genes and pathways that can guide translational diagnostics and therapeutics which can be applied into clinical problem. Current efforts are focused on polymorphisms in genes involved in DNA synthesis and repair. We have used a comprehensive genomic approach to assess the role of DNA repair capacity (DRC) in lung cancer etiopathogenesis and performed lung cancer risk assessment in hospital-based case–control studies. Our work has led us to the identification of interaction between tobacco smoke exposure and genetically susceptible subgroups that cause disease. This could further lead to the development of public health programs for protecting susceptible populations, and for targeted screening of groups at higher risk of disease.

(b) Another area of research where we are focusing is the role of SNPs and clinical outcomes in cancer patients. Lung cancer is the most common cancer amongst male malignancy and the overall survival rates are quite poor. Our primary area of research has been single nucleotide polymorphisms and tumor biomarkers and their correlation with treatment (Chemotherapy) outcomes and prognosis. Single nucleotide polymorphisms (SNPs) are one of the potential molecular markers that shall help us identify patients with unfavorable prognostic factors as well as those with poor response to chemotherapy, and therefore it might help in the selection of an appropriate chemotherapy regimen in the adjuvant and metastatic setting. We have identified SNPs of genes involved in the multistep processes of cancer genesis and the metabolism of chemotherapy that might prove clinically significant.

RESEARCH ACCOMPLISHMENTS

  1. SPONSORED RESEARCH PROJECTS COMPLETED: 48 lacs INR from Govt. agencies.
  2. DEVELOPED –Collaborative research projects with Department of pulmonary medicine, PGIMER, Chandigarh and Rajindra Medical college, Patiala
  3. Leading an independent research group in the area of Lung cancer Biomarker discovery, Etiopathogenesis of lung and breast cancer
  4. Scientific contribution includes >34 peer reviewed international publications (SCI); 4 Book chapters
  5. Research networking: Department of pulmonary medicine, PGIMER, Chandigarh and Department of Pathology, Rajindra Medical college, Patiala
  1. Research Support

Research Project

Sl No.

Title of Project

Funding Agency

Amount

Date of sanction and Duration

 

1

Association of Single Nucleotide Polymorphisms and Methylation status in the Wnt and AhR signaling pathways with risk for occurrence of Lung Cancer in a North Indian Population

ICMR

27.5 Lacs

2012-2015

 

2

Studies on anti-inflammatory responses as function of bioavailable selenium from Se-rich cereal grains

C.S.I.R

19.96

2013-2016

 

R&D SYSTEMS ADMINISTRATION

  1. As DEPUTY COORDINATOR, SCIENCE & TECHNOLOGY ENTREPRENUERS PARK (STEP) at Thapar Institute of Engineering & Technology, I had been instrument in conducting workshops in the area of medical Biotechnology apart from providing the support in day to day administration in operation of STEP.
  2. WRITING AND SUBMISSION OF GRANTS –BILATERAL / MULTILATERAL

Administrative Responsibilities:

  • PG Coordinator for Department 2018-CURRENT
  • Time-table Coordinator for Department 2013-2018
  • Placement-Coordinator for Department 2018-current
  • Student counselor, Department of Biotechnology, Thapar Institute of Engineering & Technology
  • In committee for M.tech admissions

Publications

Total Impact factor=81.07

  • Google scholar citations: 434   Google H-Factor:9

 

S.No

Author

Title

Name of Journal

Volume

Page

Year

Impact

Factor

1

Harleen Kaur Walia, Ushina Verma, Navneet Singh , Siddharth Sharma

Polymorphisms in GSTM1 and GSTT1 influence response and treatment outcome in lung cancer patients treated with platinum based chemotherapy

British Journal of Biomedical Science

Accepted

 

2019

 

1.969

2

Shweta Lawania, Amrita singh, Navneet Singh, Digambar Behera & Siddharth Sharma

The multi-faceted high order polymorphic synergistic interactions among nucleotide excision repair genes increase the risk of lung cancer in North Indians

Mutat Res Fund Mol Mech Mutagen

https://doi.org/10.1016/j.mrfmmm.2019.111673

816-818

2019

2.398

3

Noorpreet I. Dhanjal, Siddharth Sharma, Anatoly V. Skalny, Margarita G.

Skalnaya, Olga P. Ajsuvakova, Alexey A. Tinkov, Feng Zhang, Xiong Guo,

K. Sandeep Prabhu and N. Tejo Prakash

Selenium-rich maize modulates the expression

of prostaglandin genes in lipopolysaccharide stimulated

RAW264.7 macrophages

 

Food and Function

 

10

 

2839-2846

2019

3.289

4

 

S. Singh, R.S. Kaler and S. Sharma

FEM simulation analysis of fiber optic surface plasmon resonance sensor based on array of circular gold nanorod

Journal of Nanoelectronics and Optoelectronics

 

14(5)

669-674

2019

 

5

S. Singh, R.S. Kaler and S. Sharma

Resonance Effect of Bimetallic Diffraction Grating

on the Sensing Characteristics of Surface Plasmon

Resonance Sensor with COMSOL Multiphysics

Journal of

Nanoelectronics and Optoelectronics

Vol. 14,

pp. 1–6,

2019

 

6

S. Singh, R.S. Kaler and S. Sharma

A Novel Two-Dimensional Material Based

Optical Fiber Surface Plasmon Resonance Sensor for Sensing

of Organic Compounds in Infrared Spectrum Window1

Journal of Communications Technology and Electronics,

 

63

1269-1275

2018

0.4

7

Shweta Lawania, Navneet Singh, Digambar Behera & Siddharth Sharma

XPG polymorphisms and their association with lung cancer susceptibility, overall survival and response in North Indian Patients treated with platinum-based doublet chemotherapy,

Future oncology

15(2)

151-165

2019

2.313

8

Charu Bahl, Navneet Singh, Digambar Behera, Navneet Singh, Digambar Behera & Siddharth Sharma

 

Genetic variants in Wnt antagonist genes predicts the overall survival and prognosis of North Indian lung cancer patients treated with platinum based doublet chemotherapy.

Cancer Biotherapy and

Radiopharmaceuticals

33

1-10

2018

1.64

9

Shweta Lawania, Navneet Singh, Digambar Behera & Siddharth Sharma

Association of XPA Polymorphisms Towards Lung Cancer Susceptibility and its Predictive Role in Overall Survival of North Indians.

Biochemical

Genetics

56 (4)

375-396

2018

1.56

10

Amrita Singh, Navneet Singh, Digambar Behera & Siddharth Sharma..

Role of polymorphic XRCC6 (Ku70/ XRCC7 (DNAPKcs) genes towards susceptibility and prognosis of lung cancer patients undergoing platinum based doublet chemotherapy

Molecular

Biology Reports

45(3)

253-261

2018

1.9

11

Shweta Lawania, Navneet Singh, Digambar Behera & Siddharth Sharma

XPF polymorphism toward lung cancer susceptibility and survival in patients treated with platinum-based chemotherapy.

Future Oncology

14(11)

1071-1089

2018

2.13

12

Apurva Bhardawaj, Charu Bahl, Navneet Singh, Digambar Behera & Siddharth Sharma

Interactive potential of genetic polymorphism in Xenobiotic metabolizing and DNA repair genes for predicting lung cancer predisposition and overall survival in North Indians.

Mutation Research and Genetic Toxicology

826

15-24

2018

2.13

13

Amrita Singh, Navneet Singh, Digambar Behera,  Siddharth Sharma

Genetic Investigation of Polymorphic OGG1 and MUTYH Genes Towards Increased Susceptibility in Lung Adenocarcinoma and its Impact on Overall Survival of Lung Cancer Patients Treated with Platinum Based Chemotherapy.

Pathology & Oncology Research

 

doi: 10.1007/s12253-017-0372-6

2017

1.73

14

Vijay Kumar Bodal, Shruti Sangwan , Manjit Singh Bal , Mohanvir Kaur , Siddharth Sharma, Bhavleen Kaur.

Association between Microrna 146a and Microrna 196a2 Genes Polymorphism and Breast Cancer Risk in North Indian Women

Asian Pacific Journal of Cancer Prevention

18

2345-2348

2017

2.5

15

Ankita Pandey, Charu Bahl, Navneet Singh, Digambar Behera & Siddharth Sharma

Functional role of CyclinD1 polymorphism (G870A) in modifying susceptibility and overall survival of North Indian lung cancer patients.

Tumori

104(3)

179-187

2017

1.24

16

Charu Bahl, Navneet Singh, Digambar Behera & Siddharth Sharma

High order gene interactions between the genetic polymorphisms in Wnt and AhR pathway towards lung cancer susceptibility.

Personalized Medicine

14(6)

487-502

2017

1.01

17

Noorpreet Dhanjal, Siddharth Sharma, Suresh Prabhu, N Tejo Prakash.

Selenium supplementation through Se-rich dietary matrices can upregulate the anti-inflammatory responses in lipopolysaccharide-stimulated murine macrophages.

Food and Agricultural Immunology

28 (6)

1374-1392

2017

1.6

18

Sneha, CharuBahl, Navneet Singh, DigambarBehera & Siddharth Sharma

Role of sequence variations in AhR gene towards modulating smoking induced lung cancer susceptibility and Clinical outcomes in North Indian population: A multiple interaction analysis.

Current Genomics

19

313-326

2018

1.88

19

Shweta Lawania, Navneet Singh, Digambar Behera & Siddharth Sharma

XPD polymorphism towards lung cancer susceptibility survival and response in patients treated with platinum chemotherapy.

Future Oncology

13(22),

1945–1965

2017

2.13

20

Charu Bahl, Navneet Singh, Digambar Behera & Siddharth Sharma

Single Nucleotide Variations in the Wnt antagonist sFRP3 (rs7775 & rs288326) and sFRP4 (rs1802073 &1802074) genes and their association with lung cancer risk in North Indians

Meta Gene

13:

159-168

2017

 

21

Shweta Lawania, Navneet Singh, Digamba rBehera & Siddharth Sharma

XPC Polymorphism and risk for lung cancer in North Indian patients treated with platinum based chemotherapy and its association with clinical outcomes.

Pathology & Oncology Research

24(2)

353-366

2017

1.73

22

Amrita Singh, Navneet Singh, Digambar Behera & Siddharth Sharma.

Polymorphism in XRCC1 gene modulates survival and clinical outcomes of Advanced North Indian Lung cancer patients treated with platinum based doublet chemotherapy.

Medical Oncology

34 (4)

64-78

2017

2.49

23

Charu Bahl, Navneet Singh, Digambar Behera & Siddharth Sharma.

Association of candidate genetic variations in Axin2 gene with lung cancer risk in North Indian population: A multiple-interaction analysis.

Tumor Biology

39

1:18

2017

3.65

24

Amrita Singh, Navneet Singh, Digambar Behera & Siddharth Sharma.

Association and multiple interaction analysis among five XRCC1 polymorphic variants in modulating lung cancer risk in North Indian population.

DNA Repair

47:

30–41

2016

4.4

25

Charu Bahl, Navneet Singh, Digambar Behera & Siddharth Sharma.

Association of polymorphisms in Dickopff (DKK) gene towards modulating risk for lung cancer in north Indians.

Future Oncology

13 (3)

213-232

2016

2.13

26

Ankita Kumar, CharuBahl, Navneet Singh, Digambar Behera & Siddharth Sharma.

Association of p53 codon 72 polymorphism and survival of North Indian lung cancer patients treated with platinum-based chemotherapy.

Molecular Biology Reports

43

1383–1394

2016

1.82

27

Yashila Girdhar, Navneet Singh, Digambar Behera & Siddharth Sharma.

Synergistic association of CYP1A1 polymorphisms with increased susceptibility to squamous cell lung cancer in north Indian smokers.

Int J Biol Markers

31(4):

e402-e412

2016

1.47

28

Girdhar Y, Singh N, Behera D, SiddharthSharma

Combinations of the variant genotypes of CYP1A1, GSTM1 and GSTT1 are associated with an increased lung cancer risk in North Indian population: a case-control study.

Pathology & Oncology Research

22(3):

647-652

2016

1.72

29

Sharma N, Singh A, Singh N, Behera D, Sharma S.

Genetic polymorphisms in GSTM1, GSTT1 and GSTP1 genes and risk of lung cancer in a North Indian population.

Cancer Epidemiology

39(6):

947-955

2015

2.73

30

Sodhi KK, Bahl C, Singh N, Behera D, Sharma S.

Functional Genetic Variants in pre-miR-146a and 196a2 genes are associated with risk of lung cancer in North Indians.

Future Oncology

11(15):

2159-2173

2015

2.45

31

Noorpreet I. Dhanjal, Siddharth Sharma, and N. Tejo Prakash.

Quantification and In Vitro Bioaccessibility of Selenium from Osborne Fractions of Selenium-Rich Cereal Grains.

Cereal Chemistry

93 (4):

339-343

2016

1.33

32

Saronika Jindal, ShrutiSobti;Mukesh Kumar; SiddharthSharma ;Manoj Kumar Pal.

Nanocavity-Coupled Photonic Crystal Waveguide as Highly Sensitive Platform for Cancer Detection.

IEEE Sensors Journal.

16 (10):

3705-3710

2016

1.88

33

Siddharth Sharma, Shariatmadar Sherry;  KrishanAwtar.

Electronic Volume, Aldehyde dehydrogenase and Stem Cell Marker Expression in Cells from Human Peripheral Blood Apheresis Samples.

Cytometry B (Clinical Cytometry)

78B

123-129

2010

2.82

34

Krishan Awtar, Deepti Sharma, Siddharth Sharma, Ron Hamelik, ParvinGanjei- Azar, MehrdadNadji.

ALDH+/CD44+/CD24- Expression in Cells from Body Cavity Fluids.

Clinical Cytometry (Cytometry B)

78B

176-182

2010

2.82

35

Siddharth Sharma; Cabana Raquel; Shariatmadar Sherry; Krishan Awtar

Cellular volume and marker expression in human peripheral blood apheresis stem cells.

Cytometry Part A

73 (2):

160-167

2008

3.2

36

Shariatmadar Sherry;    Siddharth Sharma;Cabana  Raquel;  Powell  Scott;  Ruiz Phillip; Krishan Awtar.

Electronic volume of CD34 positive cells from peripheral blood apheresis samples.

Cytometry. Part B, Clinical Cytometry

74 (3):

182-188

2008

2.82

37

S. Agarwal*, S. Sharma*, V. Agarwal and N. Roy*both authors contributed equally

Caloric Restriction Augments ROS Defense in S. cerevisiae, by a Sir2p Independent Mechanism.

Free Radical Research

39

55-62

2005

2.949

38

R.C. Sobti,*, A.I. Al-Badran, S. Sharma, S.K. Sharma, A. Krishan, H. Mohan

Genetic polymorphisms of CYP2D6, GSTM1, and GSTT1 genes and bladder cancer risk in North India.

Cancer Genetics and Cytogenetics

156

68–73

2005

2.33

39

Sobti, R.C, Sharma, S, Jindal; 5K., and Janmeja; A.

Genetic polymorphism of the CYP1A1, CYP2ET, GSTMI and GSTTI genes and lung cancer susceptibility in North Indian population.

Molecular & Cellular Biochemistry

266

1-9

2004

2.057

40

Sobti, R.C, Sharma, S, Joshi, A., .Jindal, S.K., Janmeja, A

CYPIAI and CYP2D6 polymorphism and risk towards lung cancer in a North Indian population.

Biomarkers

8(5)

415-428

2003

2.26

41

Gill, T., Sharma, V., Mamtesh, Sharma, S., Sobti, R.C.

RAPD-PCR analysis in two species of Catopsilia.

Carologia

56:

100-105

2003

0.53

42

RC Sobti, S Sharma

Molecular markers in lung cancer.

Nucleus

43(1,2)

71-82

2000

 

43

RC Sobti, S Sharma

Molecular genetics of cancer with special reference to cancers of GI tract, Lung, Head and Neck and Cervix.

JPAS

1

63-67

2001

 

 

Average impact factor of publications=    2.13

Google citation Index: h-index=352; i-index=7

Top impact factor journals published:

S. No.

Name of the Major Journals

Impact Factor

1

Tumor biology

3.65

2

DNA Repair

4.1

3

Medical Oncology

2.64

4

Free Radical Research

3.188

5

Molecular and Cellular Biochemistry

2.67

6

Cancer Epidemiology

2.54

7

IEEE Sensors Journal

2.52

8

Clinical Cytometry

2.47

9

Future Oncology

2.131

 

 

 

 

 

 

 

 

 

 

 

Book Chapters:-

 

1. Siddharth Sharma and Awtar Krishan. Electronic Volume of Hematopoietic Stem Cells (2010). In:Flow Cytometry Applications in Stem Cell Research, Eds. Awtar Krishan, H Krishnamurthy and Satish Totey, John Wiley-Blackwell Publications.

2. Molecular genetics of Gastrointestinal Tract Cancers. (2002). In book:Some aspects of Chromosome Structure and Function. Pp 177-1 92 (Eds) Sobti, R.C. et al. Publishers (Kluwer & Narosa).

3. Telomere Telomerase and Cancer. (2002), In book: Some aspects of Chromosome Structure and Function. pp 168-191 (Eds) Sobti, R.C. et at Publishers (Kluwer & Narosa).

4. Molecular pathogenesis of lung cancer (2002). In book: Some aspects of Chromosome Structure and Function. pp 193-205 (Eds) Sobti, R.C. et at Publishers (Kluwer & Narosa).

 

REVIEWER EXPERT FOR REPUTED JOURNALS

  • Journal Cancer Management and Research
  • OncoTargets and Therapy  
  • Cancer Biotherapy and Radiopharmaceuticals
  • Archives of Medical Research
  • Journal of Clinical Laboratory Analysis

     AWARDS

  • Young Scientist award by the Panjab Academy of Sciences (PAS) 2002.
  • Post-Doctoral fellowship award by Procognia Ltd (2005-2006)
  • Post-Doctoral fellowship award by Miller school of Medicine, (2007-2009)
  • Awarded independent project grant from DST young scientist scheme on project” Role of detoxifying genes in oral cancer pathogenesis in North Indian population”.

MEMBERSHIP OF PROFESSIONAL SOCIETIES

  1. Clinical Cytometry Society, USA
  2. Member of Managing committee GGDSD college

CONFERENCE/WORKSHOP ORGANIZATION:

  • Organizing Secretary for workshop on Drug Discovery: Biotech and Pharma at CrossRoads, organized by the Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala February 21-24, 2018.
  • Co-coordinator for Summer Training Program in Advances in Modern Biotechnology May 30, 2017 - July 03, 2017 conducted by TIFAC-CORE
  • Faculty Co-ordinator in 11th Summer Project Training  in Microbial Biotechnology June 02 to July 11, 2016 STEP, Thapar University, Patiala
  • Faculty Co-ordinator Summer Training Program in area of Molecular Medicine & Computational Biology on MODERN BIOTECHNOLOGY held between 9th June 2015 to 15th July 2015 by TIFAC-CORE
  • Faculty Co-ordinator Summer Training in Industrial Biotechnology (June 02 – July 11, 2014) conducted by STEP, Thapar University
  • Faculty Co-ordinator Summer Training in Industrial Biotechnology (June 03 – July 12, 2013) conducted by STEP, Thapar University

 

CONFERENCES/SYMPOSIA/SEMINARS PARTICIPATED:

  1. Attended 3rd Lung MCMC at PGIMER, Chandigarh (March 24-25, 2018).
  2. Attended workshop on Microarray data analysis from june19-23, 2006 at IIDM, UCT.
  3. Attended workshop on statistical analysis from march10-15, 2005 at UWC
  4. Attended INDO-US workshop on Flow Cytometry (18-24 Feb, 2002 at Biotechnology Dept Panjab University)
  5. Attended workshop on Microgel (Comet assay) Electrophoresis at Dept. of Biotechnology, Panjab University, Chandigarh

 

POSTER PRESENTATIONS/ORAL PRESENTATIONS/ABSTRACTS:

  1. XPD polymorphism and its association with lung cancer risk, overall survival and response in north Indian patients treated with platinum based chemotherapy. S. Lawania, S. Sharma, N. Singh, D. Behera. Poster presentation at 2nd Indian cancer congress 08 - 12 November, 2017  Bengaluru,
  2. Role of Polymorphic Variants of BER and DSBR Pathway Genes in Modulating Lung Cancer Susceptibility and Prognosis of North Indian Population” A. Singh, S. Sharma, N. Singh, D. Behera. Presented at IASLC 18TH WORLD CONFERENCE ON LUNG CANCER, October 15-18, 2017, Yokohama, Japan.
  3. UGT1A1 gene polymorphisms and clinical outcomes in small cell lung cancer (SCLC) patients treated with irinotecan-platinum chemotherapy: The first study from north India. Navneet Singh, Ankan Bandyopadhyay, Siddharth Sharma, Digambar Behera. Abstract presentation. 2017 American Association of clinical oncology (ASCO) Annual Meeting (June 2-6, 2017) Chicago, Illinois.
  4. Genetic variants in the Wnt antagonist genes (sFRP, Dkk and Axin2) predicts the overall survival and prognosis of North Indian lung cancer patients treated with platinum based doublet chemotherapy. Charu Bahl, Siddharth Sharma, Navneet Singh, Digambar Behera. Poster Presentation at CHASCON 2017 meeting9-11 March, 2017, Panjab University, Chandigarh
  5. Se-dietary matrices can upregulate the anti-inflammatory responses in RAW macrophages. Noorpreet Dhanjal Siddharth Sharma, Sandeep Prabhu Kumble, Tejo Prakash Nagaraja. Poster Presentation at 4th International Conference on Selenium in the Environment and Human Health. (18-21 October 2015, Sao Paulo, Brazil)
  6. Synergistic association of CHRNA5 (rs16969968) polymorphism towards increased susceptibility to squamous Cell Lung Cancer in North Indian Smokers. Yashila Girdhar, Siddharth Sharma, Navneet Singh, Digambar Behera. Oral Presentation at International Conference on Advances in Biomedical Engineering, cancer Biology, bioinformatics and applied biotechnology (ABECBAB) 25-26th July 2015, JNU, New Delhi.
  7. CyclinD1 polymorphism (G870A) in modifying susceptibility and overall survival of North Indian lung cancer patients. Ankita Pandey, Siddharth Sharma, Navneet Singh, Digambar Behera. Oral Presentation at International Conference on Advances in Biomedical Engineering, cancer Biology, bioinformatics and applied biotechnology (ABECBAB) 25-26th July 2015, JNU, New Delhi.
  8. Stem cell marker expression in cells from body cavity fluids. Awtar Krishan, Deepati Sharma, Siddharth Sharma, Ronald Hamelik, Parvin Ganjei-Azar, and Mehrdad Nadji. Presented at 24th Annual Meeting of the Clinical Cytometry Society October 16–18, 2009, Jacksonville, Florida, USA.
  9. Electronic Volume and ALDH expression in Stem cells from human Apheresis samples by Siddharth Sharma, Sherry Shariatmadar, Raquel Cabana, and Awtar Krishan. Presented at The 23rd Annual Meeting of the Clinical Cytometry Society October 12–14, 2008 Portland, Oregon, USA
  10. Electronic  Volume  of  Stem  Cells  in  Human  Apheresis  Samples  by  Siddharth Sharma, Raquel Cabana, Sherry Shariatmadar, Awtar Krishan. Presented at the ISAC XXIV International Congress, May 17-21, 2008 held at Budapest Hungary
  11. Electronic Cell Volume and Marker Expression in Stem Cells from Human Apheresis Samples by Siddharth Sharma, Raquel Cabana, Sherry Shariatmadar, Awtar Krishan. Presented at the AACR at San Diego, CA, USA on April12-16 2008.
  12. Electronic  Volume  of  Hematopoietic  Stem  Cells  by  Siddharth  Sharma,  Raquel Cabana, Sherry Shariatmadar, Awtar Krishan. Presented at the 22nd  Annual Clinical Cytometry society at Washington D.C. on October 16-19 2007.
  13. “P450-BIOCHIPS by Siddharth Sharma Natasha Beeton and JM Blackburn. Presented at the international conference on “A Molecular Meander in the Midlands” organized by South African Society for Biochemistry and Molecular Biology at PeiterMaritzburg, South Africa, on July 3-56h, 2006.

INVITED LECTURE

  • Guest lecture on “Flow cytometry and its role in modern biology” delivered to department of biotechnology GGDSD College, Chandigarh 11th of November 2017.
  • Guest speaker on “Flow cytometry and its clinical applications” in 49th Annual Conference of Indian Pharmacological Society (IPSCON-2016), India Scheduled on 20th to 23rd October 2016.

ACADEMICS

  1. Teaching predominantly undergraduate (BTech) and graduate ( MTech and MSc) students subjects like; Animal Biotechnology; Animal Stem cell technology; Molecular Medicine & Diagnostics Stem cell and Tissue Engineering; Developmental Biology; Animal cell culture and transgenic technology; Virology; Diagnostic microbiology; Stem cell technology
  2. Guided > 23 postgraduate dissertations (MSc Biotechnology/ M.Tech Biotechnology/ MSc Microbiology)
  3. Supervised >2 doctoral dissertations (06 ongoing) in the area of genetic polymorphism of DNA repair, wnt signaling, drug metabolizing and transporter genes in lung cancer domain.

S.No.

Title of the thesis

Level M.E./ M.Tech./ Ph.D.

Year

Supervisor/ Co-supervisor

Completed/ ongoing

1

UGT1A1 polymorphism in small cell lung cancer patients undergoing irinotecan based chemotherapy and its association with clinical outcome

DM

2016

Co-Supervisor

Completed-Degree awarded

2

Anti-inflammatory responses of bioavailable selenium from selenium-rich cereal grains

Ph.D

2017

Co-Supervisor

Degree awarded

3

Study of the Genetic Polymorphisms and Methylation profile of Wnt signaling pathway with risk for occurrence of  Lung Cancer in North Indian Population

Ph.D

2017

Supervisor

submitted November 2017

4

Single Nucleotide Polymorphisms in the Base Excision Repair and Double Strand Break Repair pathway genes in Lung Cancer patients and their correlation with clinical outcomes

Ph.D

2017

Supervisor

Degree awarded

5

Studies on genetic polymorphism in nucleotide excision repair genes in relation to lung cancer patients

Ph.D

2017

Supervisor

Degree awarded

6

Quality Assurance and Regulatory process for Orthopedics

M.Tech

2019

Supervisor

Completed

7

Prognostic significance of MGMT & ERCC1 gene polymorphism

in lung cancer patients treated with platinu based doublet chemotherapy

M.Tech

2018

Supervisor

Completed

8

Role of TGF-β and Wnt antagonist gene sFRP4 in predicting overall survival and clinic-pathological outcomes in lung cancer patients treated with platinum based doublet chemotherapy

M.Tech

2017

Supervisor

Completed

9

Phytochemical Studies and Evaluation of Antimicrobial Potential of native and micropropagated plants of Tylophora Indica : A comparative study

M.tech

2016

Supervisor

Completed

10

Search for Novel SNPs in XPC, XPD and XPG genes

M.tech

2016

Supervisor

Completed

11

Aryl hydrocarbon Receptor gene polymorphism and its association towards Lung Cancer risk and Clinical outcomes

M.tech

2016

Supervisor

Completed

12

Prognostic role of p53 codon 72 polymorphism in North Indian Lung cancer pateints treated with platinum based chemotherapy

M.tech

2016

Supervisor

Completed

13

Synergistic association of CYP1A1 and CHRNA5 D398N genetic variants towards increased susceptibility for Lung Cancer in North Indian Population

M.tech

2015

Supervisor

Completed

14

Functional role of ccnd1 gene polymorphism (g870a) in modifying susceptibility towards lung cancer risk and overall survival of lung cancer patients

M.tech

2015

Supervisor

Completed

15

Evaluation Of SNP’s In The Phase I (CYP1A1) And Phase II (GSTM1 &GSTT1 &GSTP1) Detoxification       Genes With Risk For Occurrence Of  SCLC And NSCLC

M.tech

2014

Supervisor

Completed

16

Association of Single Nucleotide  Polymorphism  in microRNA 146a and196a2, and  it’s impact on  lung cancer in North Indian Population

M.tech

2014

Supervisor

Completed

17

Genetic polymorphism of Thymidylate Synthase gene in Lung Cancer Patients Undergoing Platinum Based Chemotherapy

   MS

2019

Supervisor

Completed

18

Cloning, Overexpression and Purification of Rnase D  in  Escherichia coli

   MS

2019

Supervisor

Completed

19

Genetic Polymorphism in NQO1 gene and its Association with
Lung Cancer  in North Indian Population

   MS

2018

Supervisor

Completed

20

Prognostic significance of ABCB1 (MDR-1) gene variants (C1236T

and G2677T) in lung cancer patients treated with platinum-based

doublet chemotherapy

   MS

2018

Supervisor

Completed

21

Predictive potential role of GSTT1 and GSTM1 genes in the overall survival and treatment outcome of lung cancer patients treated with platinum-based doublet chemotherapy

   MS

2017

Supervisor

Completed

22

Role of DNMT3B genetic polymorphism in predicting overall survival and clinic-pathological outtcomes in lung cancer patients treated with platinum based doublet chemotherapy

MS

2017

Supervisor

Completed

23

Polymorphism in the UGT1A1 gene and its association with small cell lung cancer in North Indian population

MS

2016

Supervisor

Completed

24

Evaluation of Antimicrobial and Antioxidant potential of native and micropropagated plants of Tylophora indic

MS

2016

Co-Supervisor

Completed

25

Association of Aryl Hydrocarbon Receptor gene polymorphism with the risk of Lung Cancer in North Indian population

MS

2014

Supervisor

Completed

26

Role of XRCC1 DNA repair gene polymorphisms (Arg399Gln and Arg194Trp) onoutcome of Platinum based chemotherapy for Lung cancer in North Indian Population

MS

2014

Supervisor

Completed

27

Association of micro RNA 196a2 and 146 polymorphism towards risk of breast cancer

MS

2014

Supervisor

Completed

28

Association of single nucleotide polymorphism in microrna 196a2 and 146a gene towards risk for lung cancer in north indian population

MS

2013

Supervisor

Completed

29

Association of rs2073498 ala133ser gene polymorphism with risk towards lung cancer susceptibility in a north indian population

MS

2013

Supervisor

Completed

30

Case-control study of HER2/ neu Ile655Val single nucleotide polymorphism in relation towards risk for breast cancer

MS

2013

Supervisor

Completed

31

Genetic variation in cyp1a1 gene towards risk of occurrence of lung carcinoma in north indian population

MS

2013

Co-Supervisor

Completed

32

SNP genotyping of the reck gene in lung cancer

MS

2013

Supervisor

Completed

33

Susceptibility od Foxp3 rs2294021 polymorphism in relation to breast cancer

MS

2013

Supervisor

Completed

34

Cytotoxic potential of fungal extracts against a549 cell line and its potential in drug development

MS

2013

Co-Supervisor

Completed