Dr. Mily Bhattacharya

  

Designation:

Assistant Professor

Specialization:

Biophysical chemistry, Spectroscopy, Protein and peptide-based supramolecular chemistry, Nanoscale biophysics, Protein-nanoparticle interactions

Email:

mily.bhattacharya@thapar.edu

milybh@gmail.com

Contact No.

(0175) 239-3443

Education and Training

  • 2009-2010: Research Associate; Indian Institute of Science Education and Research, Mohali.
  • 2007-2008: Scientific Associate; The Scripps Research Institute, La Jolla, CA, USA.
  • 2001-2007: Ph.D.; Indian Institute of Science, Bangalore.
  • 1998-2001: M.S. (Integrated Ph.D.) Chemical Sciences; Indian Institute of Science, Bangalore.
  • 1995-1998: B.Sc. Chemistry (Hons.); Jadavpur University, Kolkata.

Professional Affiliations

  • Assistant Professor (July 2017 – Present)
    School of Chemistry and Biochemistry, Thapar Institute of Engineering & Technology, Patiala
  • Lecturer (July 2016 – June 2017)
    School of Chemistry and Biochemistry, Thapar Institute of Engineering & Technology, Patiala
  • SERB-DST Young Scientist (October 2014 – June 2016)
    Indian Institute of Science Education and Research (IISER) Mohali, Punjab Area of research: Protein-nanoparticle interactions, Nanophotonics of protein amyloids.
  • DST-Woman Scientist (July 2010 – June 2013)
    Indian Institute of Science Education and Research (IISER) Mohali, Punjab Area of research: Biophysical chemistry of peptides & proteins and nanoscale biophysics.
  • Research Associate (July 2009 - June 2010)
    Indian Institute of Science Education and Research (IISER) Mohali, Punjab Area of research: Biophysical chemistry of protein aggregation.
  • Scientific Associate (November 2007 - January 2008)
    Department of Molecular Biology, The Scripps Research Institute, California, USA. Area of research: Synthesis of HIV protease inhibitors and precursors of catalytic antibodies.
  • Doctoral (Ph.D.) work (July 2001 - February 2007)
    Department of Inorganic & Physical Chemistry, Indian Institute of Science (IISc), Bangalore. Advisor: Prof. Puspendu K. Das Title of thesis: Quadratic nonlinearity in covalently and non-covalently linked molecules in solution Area of research: Organic supramolecular Chemistry, Materials Chemistry and Nonlinear Optics.

Teaching Activities

  • M.Sc. (Biochemistry), SCBC, Thapar Institute of Engineering & Technology:
    • PBC 103: Bioinorganic and Biophysical Chemistry (Aug-Dec 2017)
  • M.Sc. (Chemistry), SCBC, Thapar Institute of Engineering & Technology:
    • PCY 402: Advanced Topics in Chemistry (Jan-May 2017)
    • PCY 104: Quantum Chemistry (Jul-Dec 2016)
    • PCY 201: Electrochemistry and Thermodynamics (Jul-Dec 2016)
  • B.E./B.Tech., Thapar Institute of Engineering & Technology:
    • UCB 008: Applied Chemistry (Jul-Dec 2017); Tutorials & Practicals
    • UCB 008: Applied Chemistry (Jan-May 2017); Tutorials & Practicals
    • UCB 008: Applied Chemistry (Aug-Dec 2016) ; Tutorials & Practicals
  • Integrated BS-MS students, IISER Mohali:
    • CHM 101: Chemistry of elements and chemical transformations (Aug-Dec 2009, 2010)
    • CHM 201: Spectroscopic and other physical methods (Aug-Dec 2010)

List of Publications (SCI Journals)

  • “pH-responsive mechanistic switch regulates the formation of dendritic and fibrillar nanostructures of a functional amyloid”, P. Dogra, M. Bhattacharya* and S. Mukhopadhyay* J. Phys. Chem. B 2017, 121, 412-419. (* Corresponding Author) (Impact Factor: 3.177)
  • “Water rearrangements upon disorder-to-order amyloid transition”, S. Arya, A.K. Singh, T. Khan, M. Bhattacharya, A. Datta, and S. Mukhopadhyay J. Phys. Chem. Lett. 2016, 7, 4105-4110. (Impact Factor: 9.353)
  • “Direct observation of the intrinsic backbone torsional mobility of disordered proteins by fluorescence depolarization kinetics”, N. Jain, D. Narang, K. Bhasne, V. Dalal, S. Arya, M. Bhattacharya, and S. Mukhopadhyay Biophys. J. 2016, 111, 768-774.      (Impact Factor: 3.656)
  • “Self-assembly of ovalbumin amyloid pores: Effects on membrane permeabilization, dipole potential and bilayer fluidity”, M. Bhattacharya*, and P. Dogra Langmuir 2015, 31, 8911-8922. (* Corresponding Author) (Impact Factor: 3.833)
  • “Appearance of annular ring-like intermediates during amyloid fibril formation from human serum albumin”, S. Arya, A. Kumari, V. Dalal, M. Bhattacharya*, and S. Mukhopadhyay* Phys. Chem. Chem. Phys. 2015, 17, 22862-22871. (* Corresponding Author) (Impact Factor: 4.123)
  • “Conformational switching and nanoscale assembly of human prion protein into polymorphic amyloids via structurally labile oligomers”, V. Dalal, S. Arya, M. Bhattacharya, and S. Mukhopadhyay Biochemistry 2015, 54, 7505-7513. (Impact Factor: 2.938)
  • “Nanophotonics of protein amyloids”, M. Bhattacharya*, and S. Mukhopadhyay* Nanophotonics 2014, 3, 51-59. (* Corresponding Author) (Impact Factor: 4.492)
  • “Nanoscopic amyloid pores formed via stepwise protein assembly”, M. Bhattacharya*, N. Jain, P. Dogra, S. Samai and S. Mukhopadhyay* J. Phys. Chem. Lett. 2013, 4, 480-485. (* Corresponding Author) (Impact Factor: 9.353)
  • “Structural and dynamical insights into the molten-globule form of Ovalbumin”, M. Bhattacharya* and S. Mukhopadhyay* J. Phys. Chem. B 2012, 116, 520-531. (* Corresponding Author) (Impact Factor: 3.177)
  • “Nanoscale fluorescence imaging of single amyloid fibrils”, V. Dalal*, M. Bhattacharya*, D. Narang, P.K. Sharma, and S. Mukhopadhyay J. Phys. Chem. Lett. 2012, 3, 1783-1787. (*Equal Contribution) (Impact Factor: 9.353)
  • “Chain collapse of an amyloidogenic intrinsically disordered protein”, N. Jain*, M. Bhattacharya* and S. Mukhopadhyay Biophys. J. 2011, 101, 1720-1729. (*Equal Contribution) (Impact Factor: 3.656) Featured as a ‘Must Read’ article in the Faculty of 1000 (http://f1000.com/13409028)
  • “Insights into the mechanism of aggregation and fibril formation from Bovine Serum Albumin”, M. Bhattacharya, N. Jain and S. Mukhopadhyay J. Phys. Chem. B 2011, 115, 4195–4205. (Impact Factor: 3.177)
  • “pH-induced conformational isomerization of bovine serum albumin studied by extrinsic and intrinsic protein fluorescence”, M. Bhattacharya, N. Jain, K. Bhasne, V. Kumari and S. Mukhopadhyay J. Fluorescence 2011, 21, 1083-1090. (Impact Factor: 1.461)
  • “Kinetics of surfactant-induced aggregation of lysozyme studied by fluorescence spectroscopy” N. Jain, M. Bhattacharya and S. Mukhopadhyay J. Fluorescence 2011, 21, 615-625. (Impact Factor: 1.461)
  • “Quadratic nonlinearity of one- and two-electron oxidized metalloporphyrins and its switching in solution”, A. Wahab, M. Bhattacharya, S.Ghosh, A.G. Samuelson and P. K. Das. J. Phys. Chem. B 2008, 112, 2842-2847. (Impact Factor: 3.177)
  • “Enhancement of quadratic nonlinearity via multiple hydrogen bonded supramolecular complex formation”, M. Bhattacharya, A.G. Samuelson and P. K. Das J. Phys. Chem. B 2007, 111, 7122-7126. (Impact Factor: 3.177)
  • “Second order nonlinearity in oligoamides”, M. Bhattacharya and P. K. Das Synth. Met. 2005, 155, 389-392. (Impact Factor: 2.435)
  • “Synthesis and nonlinear optical properties of some donor-acceptor oxadiazoles”, S. H. Mashraqui, R. S. Kenny, S. G. Ghadigaonkar, A. Krishnan, M. Bhattacharya and P. K. Das, Opt. Mater. 2004, 27, 257-260. (Impact Factor: 2.238)

Book chapters

  • "Studying protein misfolding and aggregation using fluorescence spectroscopy" M. Bhattacharya, and S. Mukhopadhyay Reviews in Fluorescence, 2015 Chris D. Geddes (Ed.) Vol. 8, Springer International Publishing, Switzerland.
  • “Nonlinear Optical Properties of Organometallic and Metalloorganic Compounds”, M. Bhattacharya, P. K. Das and A. G. Samuelson, in Handbook of Organic Electronics and Photonics, 2008 H. S. Nalwa (Ed.) Vol. 2, American Scientific Publishers, California, USA.

Oral and Poster Presentations

  • 2016: Invited speaker; 6th International Conference on Perspectives in Vibrational Spectroscopy (ICOPVS-16), The University of Lucknow, Lucknow.
  • 2016: Poster; Optics Within Life Sciences (OWLS 2016), TIFR, Mumbai.
  • 2015: Invited speaker; Inside Raman, IISER Mohali, Punjab.
  • 2015: Oral (flash) & Poster; Challenges in Organic Materials and Supramolecular Chemistry (ISACS18), IISc, Bangalore.
  • 2014: Poster; 58th Annual Meeting of the Biophysical Society, San Francisco, California, USA.
  • 2013: Invited speaker; Conference on Condensed Matter and Biological Systems, BHU, Varanasi.
  • 2013: Poster; International Conference on Biomolecular Forms and Functions: Celebration of 50 years of the Ramachandran Map, IISc, Bangalore.
  • 2012: Poster; 56th Annual Meeting of the Biophysical Society San Diego, California, USA.
  • 2011: Poster; Fluorescence Workshop ‘FCS-2011’, ICGEB, JNU & IIT Delhi, New Delhi.
  • 2010: Poster; British Biophysical Society, Cambridge, UK.
  • 2009: Invited speaker; Chandigarh Science Congress CHASCON-2009, Panjab University, Chandigarh.
  • 2005: Poster; International Conference on ‘Optical Probes’, IISc, Bangalore.
  • 2003: Poster; National Symposium in Radiation and Photochemistry, IIT, Kanpur.

Awards/Honours/Fellowships

  • 2014: SERB-DST Young Scientists’ Grant.
  • 2014: International travel award; Biophysical Society, USA.
  • 2014: International travel award; Centre for International Co-operation in Science (CICS), Chennai.
  • 2012: International travel grant; Department of Science & Technology (DST), New Delhi.
  • 2010: International travel award; CICS, Chennai.
  • 2010: Women Scientists’ Grant (WOS-‘A’); DST, New Delhi.
  • 2003: Best poster award; National Symposium in Radiation and Photochemistry, IIT, Kanpur.
  • 2002: Vasudevamurthy-Soundararajan prize for best seminar; IPC, IISc, Bangalore.
  • 2001-2006: Junior and Senior research fellowships (JRF & SRF); Council of Scientific and Industrial Research (CSIR), New Delhi.

Sponsored Research Projects

  • “Nanoscale biophysics of protein amyloids: creating nanoparticle based amyloid superstructures”; DST-SERB Young Scientists’ Scheme, Rs. 32 Lakhs, 2014-2016.
  • “Synthesis, characterization and aggregation studies on prion octapeptide and its covalently-linked oligomers”; DST-Women Scientists’ Scheme, Rs. 22.08 Lakhs, 2010-2013.

Other Professional Activities

  • Formerly a member of the Royal Society of Chemistry, UK, Biophysical Society, USA and British Biophysical Society, UK
  • Served as a reviewer for international journals namely, Journal of the American Chemical Society, ACS Nano, RSC Advances, Journal of Physical Chemistry B, Langmuir